Low-Dose Tryptophan Depletion
نویسندگان
چکیده
منابع مشابه
Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms.
BACKGROUND Acute tryptophan depletion can induce a transient reappearance of depressive symptoms in recovered depressed patients. The neurochemical mechanism is thought to be impairment of brain serotonin neurotransmission, but the neuropsychologic mechanisms underlying the effect are unclear. METHODS To assess whether low-dose tryptophan depletion can tease out the psychological mechanisms s...
متن کاملTryptophan depletion in addictive behaviours.
We read with interest the article by Cox et al 1 and the insightful editorial by Nutt 2 and applaud both the research staff and the patients involved in this important study in view of the ethical issues and challenges in their work. They provide supportive evidence that low serotonin activity can increase dopaminergic responses to cocaine in humans, suggesting a possible mechanism specific to ...
متن کاملTryptophan catabolism in cancer: beyond IDO and tryptophan depletion.
Tryptophan catabolism in cancer is increasingly being recognized as an important microenvironmental factor that suppresses antitumor immune responses. It has been proposed that the essential amino acid tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) expressed in tumor cells or antigen-presenting cells. This metabolic pathway creates an...
متن کاملSerial reversal learning and acute tryptophan depletion.
Cognitive flexibility (i.e. the ability to adapt goal-directed behaviour in response to changed environmental demands) has repeatedly been shown to depend on the prefrontal cortex (PFC). Recent data from primate studies moreover show that depletion of prefrontal 5-HT impairs reversal learning of visual stimuli [Clarke HF, Walker SC, Crofts HS, Dalley JW, Robbins TW, Roberts AC. Prefrontal serot...
متن کاملTryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes.
BACKGROUND This study investigated the relationship between depressive symptom response during tryptophan depletion and future depressive episodes. METHODS Twelve subjects with prior major depressive episodes in remission and medication-free for > or =3 months (patients), and 12 matched healthy (control) subjects received two tryptophan depletion tests 1 week apart. During follow-up the Hamil...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2007
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2006.09.024